The Wall Street Journal reports on another gene that regulates the benefits to health and longevity produced by calorie restriction: ''This gene is absolutely essential for the response to dietary restriction [in] prolonging life span ... we're still in the identification [of genes] phase and a long way from clinical trials. ... The gene [known] ...

I'm sure you recall news and discussion - back in late 2005 - of the effects of the klotho gene on longevity in mice: ''Those mice proved to have life spans 20 percent or more longer than mice with the ordinary version of the gene ... The upper bound of life span extension in the study was 30% or so, in the same ballpark as the results of calorie ...