Scientists in Spain and Italy have identified a group of proteins in laboratory rats that could help explain two enduring medical mysteries why women live longer than men and why calorie restriction stands as the only proven method of extending longevity. Their study, which could help scientists understand the biochemical underpinnings of aging, ...

Resveratrol in high doses has been shown to extend lifespan in some studies in invertebrates and to prevent early mortality in mice fed a high-fat diet. We fed mice from middle age (14-months) to old age (30-months) either a control diet, a low dose of resveratrol (4.9 mg kg−1 day−1), or a calorie restricted (CR) diet and examined ...

A study investigating aging in mice has found that hormonal changes that occur when mice eat significantly less may help explain an already established phenomenon: a low calorie diet can extend the lifespan of rodents, a benefit that even regular exercise does not achieve. “We know that being lean rather than obese is protective from ...

Dietary restriction (DR) increases life span and delays age-associated disease in many organisms. The mechanism by which DR enhances longevity is not well understood. Results: Using bacterial food deprivation as a means of DR in C. elegans, we show that transient DR confers long-term benefits including stress resistance and increased ...

Dr. Laura Dugan, Departments of Medicine & Neurosciences at UCSD, discusses what we have learned about the aging process from lower organisms, and what is known to date about humans and calorie restriction. Targeted dietary approaches such as calorie restriction have the potential to contribute to a longer “health span” and to successful ...

Channel 4 Documentary following the revolutionary life-extension and immortality ideas of this somewhat eccentric scientist, Dr. Aubrey de Grey. This show is all about the radical ideas of a Cambridge biomedical gerontologist called Aubrey de Grey who believes that, within the next 20-30 years, we could extend life indefinitely by addressing ...

Charlie Rose engages in a round-table discussion with various scientists working on healthy life extension. Caloric restriction and resveratrol are discussed.

A film by the Immortality Institute, which examines various aspects of extreme life extension, including cryonics, caloric restriction, and transhumanism.

From the Daily Reveille: ''Pennington Biomedical Research Center conducts what Assistant Communications Director Alan Pesch called an 'exciting' two-year study on the effects of calorie restriction. The new study, CALERIE II, marks the second phase of a $12.4 million, seven-year study launched in 2002. ... Pennington researchers and others have ...

Via PLoS Medicine, a look at the benefits calorie restriction (CR) brings to mitochondrial function - and hence to your long-term health: ''A calorie-restricted diet provides all the nutrients necessary for a healthy life but minimizes the energy (calories) supplied in the diet. ... A major factor in the age-related decline of bodily functions is ...