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Rosetta: the game

  •  08-22-2007, 2:51 AM

    Rosetta: the game

    gnawing at the bars of our biological cage

    I borrowed this from Nick Bostrom's Letter from Utopia which I think beautifully expresses the transhumanist world view as I see it.

    It has been quite some time since I last posted in this thread, one of the reasons being that it also has been somewhat quiet over at Rosetta@home and in David Baker's Journal - which I think means they are busy getting on with their work, i.e., improving their protein folding methodology and designing proteins for medical (HIV vaccine, cancer related, etc.) and other (Carbon sequestration) applications. Here are some recent developments:

    Rosetta: the game

    There has been some progress with the Rosetta game which will allow users to interact with their computer and other players (!) to solve difficult protein folding problems. The above link is a first prototype with limited functionality. Also see the related Rosetta@home forum thread.

    And just an hour ago David Baker posted this enthusiastic update in the Rosetta@home journal:

    The results of the last few days of computations of Rosetta@home on your computers have been pretty amazing! In collaboration with a group at the NIH, we experimented with adding a very small amount of information about protein structures from nuclear magnetic resonance experiments to the rosetta structure prediction process. this information is fairly easily obtainable, and doesn't seem like it would have much effect, but the results show quite contrary--the models produced are extremely accurate! this has the potential to revolutionize how scientists determine protein 3D structures using NMR data. We would never have been able to test the idea, which came up in a phone conversation several months ago, without all of your contributions.

    Today I spoke at the AidsVaccine07 meeting about our work on designing vaccines. Scientists who have been working on this very challenging problem for many years are I think excited about our approach as it is something that hasn't been tried before and makes sense conceptually. While we are still far from a vaccine, our initial results with collaborators at the NIH are promising. I spoke to a reporter from the Wall Street Journal after my talk, and I think she is interested in writing an article on rosetta@home and HIV vaccine design.

    So let's keep on gnawing at those bars by running Rosetta@home on our computers...

    Those who are new to Rosetta@home and consider to join will find lots of interesting material on the Rosetta@home website. Also have a look at the first post of this thread and follow the links (Simon: it seems the links to individual forum posts don't work anymore since the Betterhumans relaunch - they all point to the top of the respective forum page. Is there a way to fix this on your side ??).

    __
    Hoelder1in

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