The near future of dentistry, as for many other fields of medicine, will prominently feature
stem cells and
tissue engineering: "Virtually all
craniofacial structures are derivatives of mesenchymal cells.
Mesenchymal stem cells are the offspring of mesenchymal cells following asymmetrical division, and reside in various craniofacial structures in the adult. Cells with characteristics of adult stem cells have been
isolated from the dental pulp, the deciduous tooth, and the
periodontium. Several craniofacial structures [have] been engineered from mesenchymal stem cells,
growth factor, and/or
gene therapy approaches. As a departure from the reliance of current clinical practice on durable materials such as amalgam, composites, and metallic alloys, biological therapies utilize mesenchymal stem cells, delivered or internally recruited, to generate craniofacial structures in temporary scaffolding biomaterials. Craniofacial tissue engineering is likely to be realized in the foreseeable future, and represents an opportunity that dentistry cannot afford to miss."
View the Article Under Discussion:
http://jdr.iadrjournals.org/cgi/content/abstract/85/11/966
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