Ouroboros points out the greater value of progeria research beyond the development of a cure for these rare conditions: "Premature aging syndromes in model organisms and humans provide insight into the mechanisms of natural aging. To the extent that progerias represent true acceleration of wildtype aging processes, they also draw our attention to genes that might someday be targeted by lifespan-enhancement strategies. ... Farnesyltransferase inhibitors, a class of drugs originally developed to attack the Ras pathway in cancer, are showing great promise in reversing the nuclear abnormalities resulting from the underlying lamin A/C mutation [of progeria]." Aging cells share some of the same characteristics as progeroid cells; time will tell just how important this will be to the development of a working rejuvation toolkit.

View the Article Under Discussion: http://ouroboros.wordpress.com/2006/09/29/the-panoply-of-progerias/
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