EurekAlert! provides more information on the role of the TOR gene in that fascinating intersection of metabolism, calorie restriction, longevity and health: "flies with the mutated form of TOR had longer life spans than control flies. ... Our study adds another dimension to TOR's activity by revealing unexpected and novel levels of beneficial regulation of insulin metabolism, by reducing insulin resistance. This study provides the first details of how TOR may regulate energy homeostasis and responses to aging, in particular the coordination of weight reduction effects caused by caloric restriction and, in humans, it may explain the effects of the Atkins diet. It suggests that reducing TOR function could lead to a possible treatment for any or all symptoms of metabolic syndrome and insulin resistance. ... reducing TOR function also blocks the age-dependent decline of heart function, providing a partial explanation for why excess calories from overeating can lead to resistance to insulin's ability to process sugars and may contribute to reduced heart function."

View the Article Under Discussion: http://www.eurekalert.org/pub_releases/2006-08/bi-ipc080206.php
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